Yes. Gain on the sale of your principal residence is tax free to the extent of your home sale exclusion. The basic exclusion of $250,000 ($500,000 on a joint return) applies only if you owned and used the home for two out of five years preceding the date of sale. However, if you haven’t yet satisfied these tests, you can prorate the exclusion for the period of time you did meet them where the sale is because of a job change. The fact that you continue to work for the same company is irrelevant.
For calendar year 2007, taxpayers covered by an HDHP may contribute up to the lesser of the annual deductible or $2,850 ($5,650 for family coverage).