If the amount of the underpayment is more than $1,000, you can avoid penalties if you’ve paid at least 90% of the tax liability for the year or 100% of 2019’s tax liability (110% if your adjusted gross income in 2019 was over $150,000, or $75,000 if married filing separately). In 2019, the IRS lowered the 90% threshold to 80%, for 2018 estimates that fell short due to confusion about new income tax withholding rules, but there is no similar reduction for 2020 taxes (nor was there a reduction for 2019 taxes).
Loss from an unforeseen and sudden event that is deductible, subject to a 10% income floor and $100 reduction for personal losses.